Limbic Rage Syndrome and Cannabis

Limbic Rage syndrome is also referred to as Episodic Dyscontrol Syndrome. It is a seizure-like disorder that affects the limbic system of the brain. When the brain is affected by this disorder, the patient experiences unpredictable and unprovoked rages. The disorder/ syndrome is mostly underestimated, undertreated and sometimes untreated, understudied, misunderstood, and mislabelled.
It should be noted that a rage can occur even with little or no warning or provocation. There can be massive repercussions that are provoked by small changes in the environment. The patients often have a mounting dysphoria (feeling unhappy). This feeling lasts for a few hours to several days. Many of the patients report that they experience hallucinations, olfactory, auditory, visual, gustatory, or multimodal just before the rage occurs.

The families of the patient may recognize the aura and anxiety of the patient as a danger signal. Most family members of the patients usually confess that the always live with the fear of incurring wrath inadvertently. The patient to live with the fear that they may lose their control leading to a panic state. These rages may last from minutes to one or two hours. During this period, the patient is totally irrational and unreachable. Family members of the patients state that during this time, any effort to soothe the patient using words becomes futile. Research shows that during the time when the patient is experiencing a rage, they ultimately display a change of personality. It has been observed that most often, victims of Limbic rage frequently kick, gouge, spit, claw and use language that is obscene. They do this with a great speed and strength and, as a result, escape is made difficult. When the patient is left alone with little or no disturbance, the attack results in exhaustion and the patient end up sleeping, sometimes with a feeling of relief. Limbic Rage syndrome is a condition that completely disrupts the victims who suffer from it as well as their family members.


1. Victims report feeling out of control of their life.
2. Sociopathic behaviour such as intolerance, frustration and violence.
3. Lesions of the frontal/ temporal lobe.

Medical Marijuana Helps in Treating Limbic Rage Syndrome
The condition can be treated. Medical marijuana is very useful in treating limbic rage syndrome. Cannabis decreases the sensory stimulation to the limbic system thereby decreasing the impact of over stimulation of the amygdala that triggers rage. It should be noted that rage is caused by a decrease in dopamine levels. When a patient suffering from limbic rage uses cannabis, there is an increase in the level of cannabinoids. Therefore, there is a competition between the dopamine and cannabinoids for binding to the dopamine transporter. In this competition, cannabinoids win, and it binds with the dopamine transporter therefore making it possible to have a normal free level of dopamine that act as a retrograde inhibitor. This leads to increased inhibition of neural input thereby decreasing the negative stimuli mostly to the cerebral cortex and midbrain. Most victims of Limbic Rage syndrome have reported that marijuana has helped them regain their control and that without marijuana they would end up killing someone or even maim themselves.